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MUSIC Dataset

Overview

MUSIC (Mitochondrial DAMPs as mechanistic biomarkers of gut mucosal inflammation) is a longitudinal adult IBD cohort study with fixed follow-up timepoints focusing on mucosal healing outcomes and comprehensive disease activity assessment.

Study ID Prefix: MID-

Key Characteristics

  • Data Structure: Fixed timepoints (timepoint_1 through timepoint_5)
  • Participants: Adults only (≥18 years)
  • Longitudinal Follow-up: Scheduled visits at baseline and follow-up intervals
  • Focus Areas: Mucosal healing, PRO2 scores, treatment response

Dataset Statistics

  • Approximate Rows: ~17,260 (all timepoints)
  • Columns: 360
  • Study Centers: Edinburgh, Glasgow, Dundee
  • Study Groups: CD, UC

Key Variables

Demographics & Baseline

  • study_id: Format MID-xxx
  • redcap_event_name: timepoint_1 through timepoint_5
  • study_group: CD or UC
  • age, sex, height, weight, bmi
  • date_of_diagnosis, age_at_diagnosis

Disease Activity Scores

  • Crohn's Disease:
  • hbi_total: Harvey-Bradshaw Index
  • Individual HBI components: hbi_abdominal_pain, hbi_liquid_stools, etc.
  • Ulcerative Colitis:
  • sccai_total: Simple Clinical Colitis Activity Index
  • mayo_total: Mayo Score
  • Individual Mayo components: mayo_stool_frequency, mayo_rectal_bleeding
  • Endoscopic Scores:
  • sescd: Simple Endoscopic Score for Crohn's Disease
  • uceis: Ulcerative Colitis Endoscopic Index of Severity
  • mayo_endoscopic_score: Mayo endoscopic subscore
  • physician_global_assessment: Remission, mild, moderate, severe
  • disease_activity: Biochemical remission, remission, active, biochemically active

Mucosal Healing Outcomes

  • endoscopic_mucosal_healing: yes/no (SES-CD or UCEIS = 0)
  • complete_mucosal_healing: yes/no/partial (endoscopic healing + normal pathology)
  • endoscopic_mucosal_healing_at_3_6_months: Outcome at timepoint_2, populated to all timepoints
  • complete_mucosal_healing_at_3_6_months: Outcome at timepoint_2
  • endoscopic_mucosal_healing_at_12_months: Outcome at timepoint_5
  • complete_mucosal_healing_at_12_months: Outcome at timepoint_5

PRO2 Scores

  • cd_pro2_raw: HBI liquid stools + HBI abdominal pain (raw)
  • cd_pro2_weighted: HBI liquid stools × 2 + HBI abdominal pain × 5 (weighted)
  • uc_pro2: Mayo stool frequency + Mayo rectal bleeding
  • ibdresponse_criteria_cd_met: Boolean for CD PRO2 criteria (liquid stools ≥4 AND pain moderate/severe)
  • ibdresponse_criteria_uc_met: Boolean for UC PRO2 criteria (stool frequency = 3 AND rectal bleeding >0)

Laboratory Values

  • Blood parameters: haemoglobin, crp, albumin, white_cell_count, etc.
  • calprotectin: Faecal calprotectin
  • calprotectin_date: Sample collection date
  • Drug levels: ifx_level, ada_level, ifx_antibody, ada_antibody
  • drug_level_date: Date of drug level testing

Medications

  • sampling_*: Medications at time of visit (1 = yes, 0 = no)
  • sampling_asa, sampling_aza, sampling_mp, sampling_ifx, sampling_ada
  • sampling_vedo, sampling_uste, sampling_tofa, sampling_mtx
  • sampling_steroids, sampling_abx, sampling_ppi
  • Baseline medication history: baseline_asa, baseline_ifx, baseline_ada, etc.

Clinical Events

  • new_flare_up: New flare since last visit
  • flare_up_1_date, flare_up_1_description: Flare details
  • unplanned_hospital_admission: Hospital admission since last visit
  • hospital_admission_1_*: Admission details
  • new_oral_steroids_since_last_visit: New steroid use

Phenotyping

  • Montreal Classification: montreal_cd_location, montreal_cd_behaviour, montreal_uc_extent, montreal_uc_severity
  • Extra-intestinal manifestations: baseline_eims_*
  • Surgical history: surgical_history_1_*, surgical_history_2_*, etc.

Investigations

  • endoscopy_date, endoscopy_type_colonoscopy, endoscopy_type_flexible_sigmoidoscopy
  • endoscopy_report, pathology_report
  • radiology_test_date: CT/MRI dates
  • mri_small_bowel, mri_pelvis, ct_abdomen_pelvis: Imaging performed
  • Radiology reports available

Patient-Reported Outcomes

  • cucq_total: CUCQ-32 total score
  • cucq_1 through cucq_32: Individual questionnaire items
  • proms_comments: Patient-reported outcome comments

Saliva Sampling

  • saliva_sample: Sample collected (1 = yes, 0 = no)
  • saliva_setting: Sample collection setting
  • sample_date: Date of saliva sample
  • Saliva-specific variables: saliva_eim, saliva_abx, saliva_piercing, etc.

Data Structure Notes

Timepoint Structure

  • timepoint_1: Baseline visit
  • timepoint_2: ~3-6 months follow-up
  • timepoint_3: ~6-9 months follow-up
  • timepoint_4: ~9-12 months follow-up
  • timepoint_5: ~12 months follow-up

Demographics DataFrame

A separate music_demographics_dataframe asset contains only timepoint_1 data with selected columns for baseline analyses.

Mucosal Healing Forward-Filling

Mucosal healing outcomes at later timepoints (3-6 months, 12 months) are forward-filled to baseline for convenience in analyses.

Study-Specific Features

  1. Mucosal Healing Focus: Comprehensive tracking of endoscopic and complete mucosal healing
  2. PRO2 Scores: Both raw and weighted PRO2 scores for CD and UC
  3. Fixed Timepoints: Consistent follow-up intervals enable temporal analyses
  4. Comprehensive Phenotyping: Detailed baseline characteristics and longitudinal tracking

Important Considerations

Disease Activity Variables

MUSIC has two disease activity variables: - physician_global_assessment: Clinical assessment (remission, mild, moderate, severe) - disease_activity: Broader classification including biochemical status

See Known Issues for comparison with other studies.

Timepoint Completeness

Not all participants have data at all timepoints. Check redcap_event_name when analyzing longitudinal trends.

Saliva Sample Data

Saliva sampling data is merged from separate REDCap instruments. Some timepoints may not have saliva data.

Data Dictionary

Pipeline Documentation

Data Access

For access requests or data questions, contact the data stewards listed in Dataset Governance.